흰 쥐의 두개골에서 평면방사 실크 차폐막을 이용한 골 유도 재생술의 골 형성 촉진 효과에 관한 연구
- 발행기관 강릉원주대학교 대학원
- 발행년도 2019
- 학위수여년월 2020. 2
- 학위명 석사
- 학과 및 전공 일반대학원 치의학과
- 실제URI http://www.dcollection.net/handler/kangnung/000000010561
- UCI I804:42001-000000010561
- 본문언어 한국어
초록/요약 도움말
The limitation of previous silk mat was that the size of silk mat was determined by the cocoon size. However, flatwise-spun silk mat (FS) has no limitation in production size. The purpose of this study was to compare FS to conventional silk mat (TDI) in terms of its physical and biological properties. Biodegradability assay, tensile strength, scanning electronic microscopic analysis, and FT-IR analysis were done. Bone regeneration was evaluated in the critical sized bone defect of rat model. FS group showed lower tensile strength and similar tensile strain to those of TDI group. When compared to TDI, FS group showed similar spectrum, but higher random coil and helix structures because of higher sericin contents. Biodegradability assay demonstrated similar behavior between FS group and TDI group. In animal model, FS group showed higher bone regeneration than TDI group in both micro-computerized tomogram and histomorphometric analysis. In conclusion, FS would have wider clinical application than TDI because of no size limitation.
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