Effect of an ibuprofen-loaded nanotube implant in diabetic rabbits
- 주제(키워드) 당뇨 , 임플란트 , 이부프로펜 , 약물 운반체
- 발행기관 강릉원주대학교 일반대학원
- 지도교수 엄흥식
- 발행년도 2018
- 학위수여년월 2018. 2
- 학위명 석사
- 학과 및 전공 일반대학원 치의학과
- 세부전공 치주과학
- 본문언어 영어
- 저작권 강릉원주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Purpose The aim of this study was to investigate the effect of an ibuprofen-loaded nanotube implant using a diabetic rabbit model. Materials and methods Twenty-six New Zealand white rabbits were treated with alloxan monohydrate to induce diabetes mellitus (DM). At 2 weeks after DM induction, three different implants (sandblasted, large-grit, and acid-etched (SLA), TiO2 anodized with ibuprofen, and machined) were placed in each rabbit. To confirm the difference in new bone formation on the implant surface, Alizarin red was administered after 3 weeks of implantation and calcein green after 6 weeks. At 8 weeks after the implantation, the rabbits were sacrificed, micro-CT analysis was performed, and tissue specimens were prepared and observed. To evaluate implant stability changes during implant placement and animal sacrifice, implant stability quotient (ISQ) values were obtained by resonance frequency analysis. Results Of the 26 rabbits treated with alloxan monohydrate, 16 died and 10 survived. All the rabbits that survived showed a blood glucose level of 300 mg/dL or higher, and the implants were placed in these diabetic animals. Although the ISQ values were higher at sacrifice than at implantation, there was no significant difference among the groups. There was also no significant difference among the groups in the volume of cortical bone around the implants in micro-CT images. The bone-to-implant contact (BIC) was significantly higher in the SLA and ibuprofen groups than in the machined group, but the difference between the SLA and ibuprofen groups was not significant. Conclusions In this study, the ibuprofen-loaded nanotube implant showed better BIC than the machined implant, but had similar responses to those of the currently used SLA implant. However, significant difference among the implants was evident in the microscopic examination only. Therefore, additional examination methods are necessary in future studies to clarify the differences among the implants.
more목차
Ⅰ. Introduction 1
Ⅱ. Materials and methods 4
Ⅲ. Results 12
Ⅳ. Discussion 18
Ⅴ. Conclusions 21
Ⅵ. Acknowledgement 22
ⅥI. References 23
Abstract in Korean 28
Abstract in English 31
