치근관내 편성 혐기성 세균에 대한 서양산 고추냉이(Horseradish, Armoracia rusticana) 뿌리 추출물의 항균 효과
The antimicrobial effect of horseradish (Armoracia rusticana) root extracts against obligate anaerobes in root canal
- 주제(키워드) Horseradish , Armoracia rusticana , Natural extract , Allyl isothiocyanate(AIT) , Obligate anaerobes , Chlorhexidine , Antibacterial effect
- 발행기관 江陵大學校 大學院
- 지도교수 朴好遠
- 발행년도 2009
- 학위수여년월 2009. 2
- 학위명 석사
- 학과 및 전공 齒醫學科
- 세부전공 小兒·靑少年齒科學 專攻
- 원문페이지 23 p.
- 본문언어 한국어
초록/요약
When the symptom of periapical infection are not released by mechanical instrumentation, anti-microbial agents including antibiosis are necessary in order to remove microorganisms from the root canal. Since anti-microbial agents of natural origins are currently popular, more natural remedies are being sought out. As it turns out, it is well known isothiocyanates (ITCs) in horseradish root extract have anti-microbial activity from many studies. In this research, anti-microbial effects of horseradish root extract and chlorhexidine, a typical anti-microbial agent, were investigated and compared against two kinds of obligate anaerobes, Fusobacterium nucleatum and Prevotella nigrescens that are often discovered in infected root canal, and Clostridium perfringens which is resistant to antibiotics and frequently used as a control strain for antibacterial studies 1. The MIC and MBC of horseradish root extract were ranged from 87 to 470 ppm and from 156 to 625 ppm against three kinds of obligate anaerobes, respectively. Horseradish root extract showed the strongest anti-bacterial activity (MBC, 156 ppm) against F. nucleatum and also showed anti-bacterial activity against antibiotic resistant obligate anaerobes, C. perfringens. 2 The MIC and MBC of chlorhexidine were ranged from 3.12 to 6.25 ppm and 10.94ppm against three kinds of obligate anaerobes, respectively. 3. The MIC with 87-470 ppm of horseradish root exact has the same growth inhibiting effect as the one of 3.12-6.25 ppm of chlorhexidine. Likewise, the MBC with 156-625 ppm of horseradish has the similar bactericidal effect as 10.94 ppm of chlorhexidine.
more목차
Ⅰ. 서론 = 1
Ⅱ. 연구 재료 및 방법 = 4
Ⅲ. 연구 결과 = 9
Ⅳ. 총괄 및 고찰 = 12
Ⅴ. 결론 = 16
Ⅵ. 참고문헌 = 17
Ⅶ. 영문초록 = 22
